Chemical Sciences: Transient Nanopatterns by Biocatalytic Self-Assembly

reportActive / Technical Report | Accesssion Number: AD1204228 | Open PDF

Abstract:

Major Goals: It was the overall aim of this research program to develop transient nanoscale patterns that change their chemical information content and functionality over time with nanoscale resolution. To achieve this, we combined pioneering work from Riedo's Lab (thermochemical nanolithography TCNL) , and Ulijn's Lab (biocatalytic self-assembly). A major goal was to provide fundamental understanding and take concrete steps towards laboratory-based mimicry of fabrication approaches used by living systems. We achieved this by exploiting similar mechanisms used by living systems (catalytic amplification, self-assembly, structural confinement) but harness them as new tools for nanoscale fabrication, in non-biological contexts. Accomplishments: The objective of this collaborative grant between the labs of Rein Ulijn (CUNY) and Elisa Riedo (NYU) was to combine revolutionary nanoscale patterning with catalytic self-assembly to obtain spatiotemporal control of nanostructure formation and breakdown and consequent dynamic control of functionality. By using thermochemical scanning probe lithography (tSPL) we were able to precisely tune the film 3D topographical landscape simultaneously with surface chemistry. This provided control over positioning and concentration of surface-immobilized enzymes [1,2]. Furthermore, by making use of competing enzyme-catalyzed assembly and disassembly reactions, we could demonstrate the transient formation of nanoscale fibers that have programmable chemical content and (electronic) functionality, as well as time programmable assembly - disassembly behavior. We studied fundamental aspects of biocatalytic assembly at solid-liquid interfaces by using both synthetic and biological surfaces and particles.

Author(s):
Riedo, Elisa ; Ulijn, Rein
Author Organization(s):
CITY UNIV OF NEW YORK
Funding Organization(s):
ARMY RESEARCH LAB RESEARCH TRIANGLE PARK NC, RESEARCH TRIANGLE PARK , NC
Document Type:
Technical Report/Final Report
Publication Date:
2021 Jun 05
Pagination:
22

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Report Number(s):
ARO-69180-CH.21
Grant Number(s):
W911NF-16-1-0113
Program Element Number(s):
PE611102
Subject Terms
Modernization Areas:
Microelectronics
Communities of Interest:
Advanced Electronics
Descriptor(s):
materials science, chemistry, chemical synthesis, materials processing, materials testing, field effect transistors, manufacturing, materials laboratories, culture techniques, nanotechnology, assembly, fabrication, metallic nanoparticles, two-dimensional materials, amino acids, self assembly, semiconductors
Keyword(s):
Transient Nanopatterns, Biocatalytic Self-Assembly, tcnl (thermochemical nanolithography), tspl (thermochemical scanning probe lithography), biofunctionalization, protein gradients, extracellular matrix, surface functionalization, biointerfaces, polydopamine, supramolecular chemistry, reconfigurable spin-textures, magnetic nanoparticles
Subject Categories:
Test Equipment, Research Facilities and Reprography; Chemistry; Biological and Medical Sciences; Test Equipment, Research Facilities and Reprography; Chemistry; Biological and Medical Sciences
Creation Date:
2023 Jun 23
Update Date:
2023 Sep 11