Biofutures

reportActive / Technical Report | Accession Number: ADA392937 | Open PDF

Abstract:

The goal of the 2000 JASON summer study on Biofutures was to explore prospects for computer modeling of cellular biochemical networks and to ask more generally about the role of modeling in biology. Indeed, it is far from clear that reductionist models from the physical sciences are the right paradigm -- methodologies taken from operations research or electrical engineering may be more relevant 2. Comments on modeling from biologists range from complaints about the lack of biological realism to categorical statements that groups who do not buy into these developments are going to be left behind. A majority of biologists are quite skeptical about the utility of models, notwithstanding the success of, for example, the Hodgkin-Huxley model of electrical impulses in nerve cells.

Author(s):
Nelson, D. ; Hwa, T. ; Abarbanel, H. ; Block, S ; Dyson, F.
Author Organization(s):
MITRE CORP MCLEAN VA JASON PROGRAM OFFICE
Supplementary Note:
--Original contains color plates: All DTIC reproductions will be in black and white.
Pagination:
0057

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
JSR-00-130
Monitor Series:
DARPA
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1.2.7_Experimentation; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_5.2.2_Develop Knowledge and Situational Awareness; JCA_5.2_Understand; JCA_1.2.6_Concepts; JCA_4.6_Engineering
Modernization Areas:
Microelectronics
Communities of Interest:
Ground and Sea Platforms
Descriptor(s):
*COMPUTERIZED SIMULATION, *BIOCHEMISTRY, NERVE CELLS, OPERATIONS RESEARCH, CELLS(BIOLOGY), ELECTRICAL ENGINEERING
Field(s)/Group(s):
Biochemistry, Computer Programming and Software
Keyword(s):
HODGKIN HUXLEY MODEL
Report Date:
2001 Jun 01
Creation Date:
2001 Aug 15