Purity Analysis of MNG and Chemical Analysis of MNG and MNNG in Biological Samples.

reportActive / Technical Report | Accession Number: ADA256343 | Open PDF

Abstract:

Currently N-methyl-N-nitroguanidine MNG is being considered by the Air Force Armament Laboratory for use in explosive formulations. The Toxic Hazards Research Unit THRU has been asked to develop a mammalian toxicity profile of MNG that includes the analysis of chemical impurities, and an assessment of the potential for the metabolism of MNG to 1-methyl-3-nitro-l- nitrosoguanidine MNNG. Potential in situ gastric conversion of MNG to MNNG is a toxicological concern because MNNG is both mutagenic and carcinogenic. N- methyl-N-nitroguanidine was analyzed by high performance liquid chromatography and small amounts of guanidine, methylguanidine, and nitroguanidine were detected. The conversion of MNG to MNNG was investigated by dosing Fischer 344 rats orally with MNG. Gastric contents, feces, and urine were analyzed from these animals. No evidence of conversion of MNG to MNNG was detected in any of the samples analyzed. MNG, N-methyl-N-nitroguanidine MNNG, 1-methyl-3-nitro-1- nitrosoguanidine Metabolism of MNG gastric conversion of MNG to MNNG HPLC analysis of MNG, MNNG, and other guanidines

Author(s):
Brashear, W. T. ; Lu, P. P. ; Ketcha, M. M.
Author Organization(s):
MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
Descriptive Note:
Final rept. May-Nov 1991,
Pagination:
0022

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AL**-TR-1992-0060
Contract/Grant Number(s):
F33615-90-C-0532
Task Number(s):
01
Project Number(s):
6302
Monitor Series:
TR-1992-0060, AL**
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.3.2_Personnel Management
Modernization Areas:
Quantum Science and Computing
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*EXPLOSIVES, *PURITY, *NITROGUANIDINE, CONVERSION, AIR FORCE, HAZARDS, TOXIC HAZARDS, MAMMALS, RATS, ANIMALS, GUANIDINES, CHROMATOGRAPHY, URINE, FECES, CHEMICAL ANALYSIS, LABORATORIES, LIQUID CHROMATOGRAPHY, METABOLISM, CHEMICALS, LIQUIDS, TOXICITY, FORMULATIONS, IMPURITIES
Field(s)/Group(s):
Medicine and Medical Research, Toxicology, Organic Chemistry
Keyword(s):
*MNG(N METHYL N NITROGUANIDINE), *MNNG(1 METHYL 3 NITRO 1 NITROSOGUANIDINE), BIOLOGICAL SAMPLES, GASTRIC CANCER, PE62202F, WUAL63020174
Report Date:
1992 Apr 01