Classes and Properties of Human Antibodies.

reportActive / Technical Report | Accession Number: ADA072071 | Open PDF

Abstract:

Multiple injections of ovomucoid were given to mice with ongoing prolonged IgE antibody production to that antigen. Two inbred strains and antigen doses ranging from 0.05 to 5 micrograms each injection, given intradermally and subcutaneously, were used. Mice treated in this manner showed a marked diminution of the IgE antibody booster response as compared to controls. This decrease in booster response was antigen-specific. In addition, a protective effect from anaphylaxis was indicated. The mouse model continues to be a valuable tool for studies of certain IgE-mediated diseases. Author

Author(s):
Levine, Bernard B.
Author Organization(s):
NEW YORK UNIV N Y SCHOOL OF MEDICINE
Descriptive Note:
Annual rept. Jun 74-Jul 75,
Pagination:
0018

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-74-C-4070
Task Number(s):
00
Project Number(s):
3A161102B71Q
 Subject Terms
Joint Capability Areas:
JCA_1.2_Force Preparation; JCA_1_Force Support
Communities of Interest:
Biomedical
Descriptor(s):
*ANTIBODIES, *IMMUNOLOGY, MODELS, HUMANS, MICE, ANTIGENS, ALLERGIC DISEASES
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
WU143, AS71Q, PE61102A
Report Date:
1975 Jul 01