Commentary: What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence

Melderen, Laurence V.; Wood, Thomas K.

Commentary: What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence

Active / Technical Report | Accession Number: AD1057984 |

Open PDF

Abstract:

In a recent paper published in Frontiers in Microbiology, Ramisetty et al. 2016 questioned the mainstream model regarding bacterial persistence proposed by the group of K. Gerdes Maisonneuve et al., 2011, 2013. Persistence is an important phenomenon thought to contribute to infectious diseases chronicity and antibiotic resistance selection Michiels et al., 2016. This reversible and low frequency phenotypic switch allows bacteria to enter a particular physiological state in which they can sustain the presence of a given antibiotic Kaldalu et al., 2016Wood, 2016.

Author(s):

Melderen, Laurence V. ; Wood, Thomas K.

Author Organization(s):

Universit Libre de Bruxelles (ULB) Gosselies Belgium

Descriptive Note:

Journal Article - Open Access

Supplementary Note:

Frontiers in Microbiology , 8, 01 Jan 0001, 01 Jan 0001,

Pagination:

0003

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

Distribution Statement:

Approved For Public Release;

RECORD

Collection: TR

Subject Terms

Joint Capability Areas:

JCA_1_Force Support; JCA_1.3_Human Capital Management; JCA_1.2_Force Preparation; JCA_1.3.2_Personnel Management; JCA_1.2.3_Educating; JCA_6.1.3_Switching and Routing; JCA_6_Net Centric; JCA_5.3_Planning; JCA_5_Command and Control; JCA_6.1_Information Transport

Modernization Areas:

Biotechnology

Communities of Interest:

No COI(s) Identified

Descriptor(s):

antitoxins, TOXINS AND ANTITOXINS

Field(s)/Group(s):

Microbiology

Keyword(s):

lon protease, persistence, TA(toxin antitoxin), poly phosphate

Report Date:

2017 Feb 14

Creation Date:

2018 Aug 16