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/Title (Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression)
/Author (Kobayashi, Tatsuya)
/Keywords (cartilage;health services;medical personnel;disease attributes;pain;arthritis;biomedical research;bone and bones;connective tissue cells;demographic cohorts;electronic mail;fluid flow;shear stresses;stresses;validation;abstracts;diseases)
/Subject (The purpose of this project is to determine the roles of Piezo mechano-sensing channels in osteoarthritis \(OA\) and pain associated with OA using mouse genetic models. Two major aims are proposed. 1\) assessment of the effect of cartilage-specific loss of Piezo1 and Piezo2 in OA progression in surgically created OA in mice, and 2\) assessment of OA-associated pain in Piezo2 haplo-insufficient mice.)
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