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/Author (Goldman, Samuel M.)
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/Title (Integrating Environmental, Genomic, and Functional Data to Characterize Individual Risk for Parkinson's Disease)
/Keywords (parkinson's disease;proteins;abstracts;pesticides;biomedical research;cell line;cells;dermatologic agents;diseases;transcription factors;cell movement;department of defense;dieldrin;electronic mail;genetic variation;information operations;whole genome sequencing)
/Subject (The overall purpose of this work is to characterize which individuals may be susceptible to specific toxic insults, and the underlying mechanisms. We have three Aims: 1\) use iPSC-derived neuronal cell lines to validate and extend our prior work that found an 11-fold increased risk of Parkinson's disease \(PD\) in persons exposed to the herbicide paraquat who lacked functional glutathione-S-transferase T1 \(GSTT1\), a key metabolic enzyme with anti-oxidant function; 2\) perform whole genome sequencing of existing DNA specimens from a PD study with highly characterized pesticide exposures, using bioinformatic tools to identify likely functional gene-environment interactions; and 3\) test our predictions using iPSC-derived neuronal cell lines that model these genetic variations, and exposing cellular lines to these same environmental agents. This is a partnering PI project with W81XWH-20-1-0710. The scope of the -0709 project is to accomplish Aim 2.)
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