Concomitant Topical Treatment of Pain and Inflammation in Ocular Injuries

Corneal injuries being exceptionally painful and debilitating, often trigger a severe inflammatory response, leading to permanent visual damage. Substance P (SP) - a neuropeptide is known for its implication in inflammation and nociception. We hypothesize that the antagonism of neurokinin -1 receptor (NK1R), SPs preferred receptor, can suppress nociception, reduce inflammation, and promote wound healing following corneal injuries. We aim to study NK1R antagonist topical treatment in two injury models: mechanical and chemical (alkali burn). In aim 1, we focus on the analgesic efficacy of NK1R antagonism and its effect on corneal nerves. In aim 2, we explore the anti-inflammatory properties of NK1R antagonism and its effect on corneal wound healing. Our findings have revealed that elevation of SP in the cornea is correlated with pain sensation in corneal injuries. Inhibiting SP receptor - NK1R helps treat ocular pain following mechanical and chemical corneal injuries.