Targeting Regulatory T Cells to Treat Chronic Migraine and Post Traumatic Headache

reportActive / Technical Report | Accesssion Number: AD1210805 | Open PDF

Abstract:

In this study we propose to test the hypothesis that that reduced regulation of immune homeostasis by regulatory T (Treg) cellsat peripheral tissues contributes to the chronification of headache and cognitive impairment in chronic migraine (CM) and posttraumatic headache (PTH). The research objective is to validate Treg as a cellular target for novel, peripherally active therapy for CM and PTH, with mechanisms distinct from the existing treatment options. We made significant progress during the last funding period. First, we have found that mild traumatic brain injury (mTBI)resulted in astroglial and microglial activation in hippocampus and cortex (Aim 1A), both were inhibited by the low-dose interleukin-2 (LD-IL-2) treatment, suggesting that LD-IL-2 mitigates mTBI-induced deficit through inhibition of inflammatory responses in the brain.

Author(s):
Cao, Yu-qing
Author Organization(s):
WASHINGTON UNIV ST LOUIS MO
Funding Organization(s):
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD, FORT DETRICK, MD
Document Type:
Technical Report/Annual Report
Publication Date:
2023 Aug 01
Pagination:
9

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DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release.
Copyright: Not Copyrighted

RECORD

Collection: TRECMS
Subject Terms
Descriptor(s):
brain injuries, medical personnel, peptide growth factors, lymphocytes, cognitive impairment, cells, headache disorders, biomedical research, blood, targeting, growth factors, hippocampus, immunohistochemistry, law, maryland, neuroglia
Keyword(s):
Chronic migraine, post-traumatic headache, mild-traumatic brain injury, cognitive defect, regulatory T cell, trigeminal ganglion
Subject Categories:
Biological and Medical Sciences; Biological and Medical Sciences
Descriptor(s):
brain injuries, medical personnel, lymphocytes, cognitive impairment, cells, headache disorders, biomedical research, blood, peptide growth factors, targeting, hippocampus, law, maryland, neuroglia, pain, professional development, statins
Creation Date:
2023 Sep 20
Update Date:
2023 Nov 09