Mechanisms of Adstiladrin Sensitivity and Resistance in Bladder Cancer

reportActive / Technical Report | Accesssion Number: AD1190570 | Open PDF

Abstract:

Our hypothesis is that Adstiladrin works by novel mechanisms of action that involve both the innate and adaptive arms of the immune system, and that acquired resistance involves metabolic plasticity resulting in downregulation of fatty acid biosynthesis. Our objectiveis to use genomic and metabolomic approaches to identify these mechanisms in order to develop biomarkers for patient selection and novel targets for future combination therapies. Our Specific Aims are: (1) Perform genomic and metabolomic analyses on tumors and urine from thePhase 3 clinical trial; (2) Comprehensively characterize the effects of Ad-IFN on the tumor immune microenvironment; and (3) Define the role of fatty acid metabolism in Ad-IFN-induced cell death.

Author(s):
Mcconkey, David
Author Organization(s):
JOHNS HOPKINS UNIV BALTIMORE MD
Funding Organization(s):
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD, FORT DETRICK , MD
Document Type:
Technical Report/Annual Report
Publication Date:
2022 Aug 01
Pagination:
12

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
biomedical research, bladder cancer, clinical trials, gene expression, neoplasms, dna sequence analysis, medical personnel, students, universities, biological markers, cancer, cell physiological processes, fatty acids, gene therapy, maryland, nucleic acids, patent applications
Creation Date:
2023 Jan 20
Update Date:
2023 Jan 20