Card19 is a Regulator of MICOS Complex Proteins and Protects Against Mitochondrial Dysfunction in Macrophages

reportActive / Technical Report | Accesssion Number: AD1186131 | Open PDF

Abstract:

CARD19 is a protein of unknown function that was first reported in 2003 to interact with BCL10 and inhibit NF-B in Jurkat T cells (196). Later investigation indicated the cDNA employed in the initial study represented an incompletely spliced mRNA product (30; 138). The fully spliced mRNA encoded a protein which localized to the mitochondria and endoplasmic reticulum in HeLa cells (30). Gene expression databases report that CARD19 is highly transcribed in both human and murine myeloidcells (46; 161; 176).

Author(s):
Rios, Kariana
Author Organization(s):
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
Funding Organization(s):
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD, BETHESDA , MD
Document Type:
Technical Report/Doctoral Thesis
Publication Date:
2021 Mar 12
Pagination:
166

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DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
chemistry, chemical synthesis, cell physiological processes, cells, lymphocytes, parkinson's disease, proteins, neurodegeneration, biomedical and dental materials, blood, body fluids, genetics, mass spectrometry, proteomics, cell membrane, liver diseases, polymeric films
Subject Categories:
Biological and Medical Sciences
Creation Date:
2022 Nov 28
Update Date:
2023 Feb 08