Mesoscale Nanotechnology: A Novel Therapeutic Strategy in Polycystic Kidney Disease

reportActive / Technical Report | Accesssion Number: AD1169500 | Open PDF

Abstract:

Aim 1. Evaluate therapeutic efficacy of nanoparticle-targeted mTOR inhibition in a rat model of PKD Mesoscale nanoparticles will be synthesized to encapsulate an ASO against mTOR. We will use the PCK-Pkhd1pck rat model of PKD that closely mimics ADPKD in humans. Efficacy will be evaluated by longitudinal serial live imaging via MRI, as well as post-mortem phenotypic surrogate markers of renal cystogenesis. Aim 2. Evaluate therapeutic efficacy of nanoparticle-targeted miR-17 inhibition in a rat model of PKD Mesoscale nanoparticles will be synthesized to encapsulate an oligonucleotide against miR-17. Just like in Aim 1 we will use the Pkhd1pck/pck rat model of PKD that closely mimics ADPKD in humans. Efficacy will be evaluated by longitudinal serial live imaging via MRI, as well as post-mortem phenotypic surrogate markers of renal cystogenesis.

Author(s):
Jaimes, Edgar A.
Author Organization(s):
SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK
Funding Organization(s):
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD, FORT DETRICK , MD
Document Type:
Technical Report/Annual Report
Publication Date:
2022 May 01
Pagination:
36

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Grant Number(s):
W81XWH-21-1-0188
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
health services, medical personnel, kidney diseases, animal diseases, breast cancer, covid-19, stem cells, electronic cigarettes, cells, therapy, biomedical research, cancer, detection, diseases and disorders, neoplasms
Keyword(s):
ADPKD(ADULT POLYCYSTIC KIDNEY DISEASE)
Subject Categories:
Biological and Medical Sciences; Biological and Medical Sciences
Creation Date:
2022 May 23
Update Date:
2022 Jul 06