The Role of the Gut Microbiome in Colorectal Cancer

reportActive / Technical Report | Accesssion Number: AD1168856 | Open PDF

Abstract:

Inflammatory bowel disease (IBD) is a chronic condition of the gastrointestinal tract that predisposes individuals to develop CRC. Chronic inflammation is one of the key hallmarks of cancer and dysbiosis of the gut microbiome is proposed to promote CRC. The prevalence of IBD has increased 2- to 3-fold among veterans. The objective of this proposal is to utilize Il10-/- mice, a model of human IBD, together with Stat2-/- mice, which are more resistant to CRC to: 1) identify unique microbial communities in the gut and 2) metabolites of bacterial and host origin that mediate anti-inflammatory and antitumor effects to control inflammation and drastically reduce the risk of CRC development.

Author(s):
Gamero, Ana
Author Organization(s):
TEMPLE UNIV OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION PHILADELPHIA PA
Funding Organization(s):
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD, FORT DETRICK , MD
Document Type:
Technical Report/Final Report
Publication Date:
2021 Nov 01
Pagination:
15

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Grant Number(s):
W81XWH-18-1-0240
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
genetics, microbiomes, biomedical research, body weight, gut microbiome, colon cancer, professional development, covid-19, gastrointestinal tract, students, education, training, breeding, cancer, deficiencies, inflammation, maryland
Keyword(s):
Colorectal, cancer, microbiota, dysbiosis, colitis, chronic, ibd(inflammatory bowel disease)
Subject Categories:
Biological and Medical Sciences
Creation Date:
2022 May 16
Update Date:
2022 Jun 24