Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression

reportActive / Technical Report | Accesssion Number: AD1159625 | Open PDF

Abstract:

The purpose of this project is to determine the roles of Piezo mechano-sensing channels in osteoarthritis (OA) and pain associated with OA using mouse genetic models. Two major aims are proposed.1) assessment of the effect of cartilage-specific loss of Piezo1 and Piezo2 in OA progression in surgically created OA in mice, and 2) assessment of OA-associated pain in Piezo2 haplo-insufficient mice.

Author(s):
Kobayashi, Tatsuya
Author Organization(s):
MASSACHUSETTS GENERAL HOSPITAL BOSTON
Funding Organization(s):
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD, FORT DETRICK , MD
Document Type:
Technical Report/Annual Report
Publication Date:
2021 Oct 01
Pagination:
9

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Grant Number(s):
W81XWH-19-1-0186
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
medical personnel, cartilage, health services, pain, biomedical research, arthritis, students, diseases and disorders, animals, breeding, genetics, laboratory animals, management personnel, maryland, organizational structure, professional development, targeting
Keyword(s):
Osteoarthritis, mouse, genetic models, mechano-sensing ion channel, Piezo1, Piezo2, pain, joint, synovia
Subject Categories:
Biological and Medical Sciences
Creation Date:
2022 Feb 14
Update Date:
2022 Mar 01