A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

reportActive / Technical Report | Accesssion Number: AD1158225 | Open PDF

Abstract:

Objective: Systemic low-grade inflammation is a prostate cancer risk factor in men of African descent, and correlates with West Africanancestry, genetic susceptibility, a distinct tumor biology, and aggressive disease. Our overall objective is to understand these relationshipswith a view to informing prevention and therapeutic strategies. Impact: Our study will be the first to explore the relationship between systemic/chronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammation and tumor biology affects prostate cancer progression in a high-risk population, like African-American men, offers the opportunity to the develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.

Author(s):
Ambs, Stefan
Author Organization(s):
GENEVA FOUNDATION TACOMA WA
Funding Organization(s):
ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD, FORT DETRICK , MD
Document Type:
Technical Report/Annual Report
Publication Date:
2021 Oct 01
Pagination:
95

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Grant Number(s):
W81XWH-18-1-0588
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
health services, medical personnel, cell physiological processes, chemistry, genetics, ethnic groups, geography, disease attributes, biological factors, minority groups, oncology, vaccines, chemical synthesis, gut microbiome, microbiomes, breast cancer
Keyword(s):
disease progression, tumor biology, transcriptome, whole exome sequencing
Subject Categories:
Biological and Medical Sciences
Creation Date:
2022 Feb 01
Update Date:
2022 Feb 16