Intramuscular Pharmacokinetics of Naltrexone in the African Green Monkey (Chlorocebus aethiops sabeus)

reportActive / Technical Report | Accesssion Number: AD1157626 | Open PDF

Abstract:

The pharmacokinetics of intramuscular naltrexone human equivalent doses (HEDs) of 2, 10, and 20 mg were evaluated in adult male African green monkeys.Strong dose-linearity was observed between the injected naltrexone dose and plasma concentration maximum (Cmax). Absorption was rapid, with time to maximum concentration (Tmax) approximating 14 minutes for the 10 and 20 mg HEDs. Intramuscular administration of naltrexone in this laboratory non-human primate model exhibited orderly and predictable plasma kinetics. The inclusion of 10 and 20 mg HEDs allows for confident predictions of plasma levels at a bolus intramuscular dose above those commonly administered but potentially required for severe opioid exposure.

Author(s):
Langston, Jeffrey L. ; Moffett, Mark C. ; Makar, Jennifer R. ; Bullock, Katherine N. ; Pennington, M. R. ; Myers, Todd M.
Author Organization(s):
US Army Medical Research Institute of Chemical Defense
Funding Organization(s):
Defense Threat Reduction Agency, Fort Belvoir , VA
Document Type:
Technical Report/Technical Report
Publication Date:
2022 Jan 12
Pagination:
14

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Grant Number(s):
CB3950
Subject Terms
Communities of Interest:
Biomedical
Descriptor(s):
biomedical research, alkenes, governments, threats, animals, opioids, department of defense, drug abuse, emergencies, kinetics, medical countermeasures, monkeys, pharmacokinetics, rhesus monkeys, terminals, clinical trials, elimination
Keyword(s):
rescue therapy, Intramuscular Pharmacokinetics, Naltrexone, African Green Monkeys, hed (human equivalent doses)
Subject Categories:
Biological and Medical Sciences; Biological and Medical Sciences
Creation Date:
2022 Jan 26
Update Date:
2022 Feb 16