Sensitivity Analysis for a Time-Dependent Physiological Model of Superficial Thermal Burns

reportActive / Technical Report | Accesssion Number: AD1153297 | Open PDF

Abstract:

Methods of sensitivity analysis were applied to the reduced time-dependent physiological model describing the local inflammatory response and early fibroblast activity triggered by a first-degree thermal burn. Results of these methods will be used to advance the parameter estimation process as well as identify potential avenues for experiments to support model development. This model will serve as a foundation for building physiologically driven models developed by DTRA to predict casualty distributions after a nuclear detonation event.

Author(s):
Creel, Amy ; Reynolds, Angela ; Jennings, Rachel
Author Organization(s):
Applied Research Associates
Funding Organization(s):
Defense Threat Reduction Agency, Fort Belvoir , VA
Document Type:
Technical Report/Technical Report
Publication Date:
2022 Oct 01
Pagination:
72

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Report Number(s):
DTRA-TR-21-063
Contract Number(s):
HDTRA1-14-D-0003
Subject Terms
Modernization Areas:
Directed Energy
Communities of Interest:
Biomedical
Descriptor(s):
medical personnel, systems biology, burns, cells, thermal burns, wound infections, computational science, leukocytes, blood cells, computational biology, wound healing, wounds and injuries, blood, diseases and disorders, equations, lymphocytes, nuclear weapons
Keyword(s):
ODE (ordinary differential equations), Global sa, sa (Sensitivity Analysis), Local sa, tdpm (Time-Dependent Physiological Models), first-degree thermal burns
Subject Categories:
Biological and Medical Sciences; Mathematical and Computer Sciences
Creation Date:
2021 Nov 19
Update Date:
2022 Nov 03