Anesthetic Management of Catecholaminergic Polymorphic Ventricular Tachycardia in Pregnancy

reportActive / Technical Report | Accesssion Number: AD1151857 | Open PDF

Abstract:

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare familial or de novo mutation in either the cardiac RyR2 Ryanodine gene (CPVT1) or CASQ2 calsequestrin gene (CPVT2). Both of these mutations alter normal cardiac myocyte calcium regulation, enhancing the propensity of sarcoplasmic reticulum calcium to be released. These spontaneous calcium discharges cause unpredictable malignant arrhythmias presenting as syncope or sudden cardiac death.

Author(s):
Hood, Courtney R. ; Nagy, Christopher J.
Author Organization(s):
59th MDW
Funding Organization(s):
AIR FORCE MEDICAL WING (59TH) WILFORD HALL AMBULATORY SURGICAL CENTER, LACKLAND AFB , TX
Document Type:
Technical Report/Technical Report
Publication Date:
2021 Nov 01
Pagination:
1

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Report Number(s):
21275
Subject Terms
Communities of Interest:
Biomedical
Descriptor(s):
cardiac arrhythmias, cardiac arrest, pregnancy, therapy, air force, department of defense, education, gene therapy, mutations, telemetry, epinephrine, pathophysiology
Keyword(s):
Minimize parturient stress and pain, Avoid arrhythmogenic medications, beta blocker therapy, Metoprolol, propranolol
Subject Categories:
Biological and Medical Sciences
Creation Date:
2021 Nov 03
Update Date:
2022 Feb 22