The Molecular Mechanism of PRDM9 During Meiosis in the Mouse

reportActive / Technical Report | Accesssion Number: AD1128404 | Open PDF

Abstract:

Meiotic homologous recombination is vital for accurate segregation of the homologous chromosomes in the first meiotic division, and infertility, miscarriage and developmental disabilities can result when this process is impaired. Additionally, meiotic homologous recombination generates genetic diversity. During meiosis, recombination predominantly occurs at recombination hotspots determined by the DNA-binding protein PRDM9, which is essential for fertility. PRDM9 marks where homologous recombination can occur with a histone modification, H3K4me3.

Author(s):
Thibault-sennett, Sarah
Author Organization(s):
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
Funding Organization(s):
Publication Date:
2017 Oct 11
Pagination:
0

Security Markings

RECORD

Collection: TRECMS
Subject Terms
Modernization Areas:
Autonomy
Communities of Interest:
No COI(s) Identified
Descriptor(s):
genetics, embryos, cells, chromosomes, chromosome structures, stem cells, cell physiological processes, chemistry, testes, germ cells, biology, gene expression, proteins, sex glands, spermatozoa, biochemistry, genomics
Update Date:
2021 May 14