Discovery of Novel Therapeutics for Disordered Sleep in Fragile X Syndrome

reportActive / Technical Report | Accesssion Number: AD1117748 | Open PDF

Abstract:

Fragile X syndrome is the single gene disorder that cause sleep and circadian deficits in both humans and Drosophila melanogaster. In this project we employed the enormous benefits of this model system to perform a large-scale drug screen. Here we identify from a large scale in vivo drug screen compounds that replicably alter sleep and circadian rhythms in Fragile X mutants. Initial studies indicate that some of these effects may be evident in Fragile X flies but not in wild-type.

Author(s):
Allada, Ravi ; Saurabh, Sumit
Author Organization(s):
Northwestern University
Funding Organization(s):
Publication Date:
2020 Sep 01
Pagination:
0

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RECORD

Collection: TRECMS
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
therapy, biomedical research, human behavior, autism, diseases and disorders, fragile-x syndrome, students, universities, data analysis, diptera, medical personnel, professional development, small molecules, genes, intellectual disability, maryland, molecules
Keyword(s):
fxs (Fragile-X Syndrome), Autism Spectrum Disorders, Drug Screen, FDA small molecule compounds, fda (food and drug administration), Drosophila melanogaster, fmr (Fragile Mental Retardation), fmr gene
Subject Categories:
Biological and Medical Sciences; Biological and Medical Sciences
Update Date:
2021 Jan 21