Diagnosis of Late-Stage, Early-Onset, Small-Fiber Polyneuropathy

reportActive / Technical Report | Accesssion Number: AD1094831 | Open PDF

Abstract:

The goal of this study is to determine the prevalence of longstanding early-onset small-fiber polyneuropathy (SFPN) in Veterans with Gulf War Illness and to translate this information clinically by developing and validating tools to diagnose SFPN more quickly and reliably. Study participants will undergo several tests to determine occurrence of SFPN, specifically Autonomic Function Testing and skin biopsy to detect morphology and count of nerve endings. These tests will be compared to a symptom evaluation questionnaire for SFPN, a neurological exam that measures muscle strength and the ability to feel different sensations, genomic markers specific to SFPN, and pupil measurements including diameter and constriction. Our new screening tools will provide a precise measure of SFPN in a less invasive, more rapid approach to diagnosing small-fiber polyneuropathy in Veterans with Gulf War Illness.

Author(s):
Serrador, Jorge M. ; ,
Author Organization(s):
Veterans Biomedical Research Institute
Funding Organization(s):
Publication Date:
2019 Dec 01
Pagination:
0

Security Markings

RECORD

Collection: TRECMS
Subject Terms
Modernization Areas:
Biotechnology
Communities of Interest:
Biomedical
Descriptor(s):
biomedical research, medical personnel, neuropathy, peripheral nervous system, health services, institutional review board, blood flow, data analysis, patent applications, persian gulf syndrome, physical examination (medicine), professional development, biotechnology, cardiovascular physiological phenomena, heart rate, law, maryland
Keyword(s):
peripheral neuropathy, Polyneuropathy, gulf war illness, autonomic, skin biopsy, pupilometry, gene polymorphisms
Subject Categories:
Biological and Medical Sciences
Update Date:
2020 Apr 17