Development of Novel PD1/PD-L1 Antagonists Using Circular Cys-Knotted Micro Proteins

reportActive / Technical Report | Accesssion Number: AD1050207 | Open PDF

Abstract:

During this first year we have constructed genetically-encoded libraries using the loops 1 and 5 of cyclotide MCoTI-I. We have also accomplished the design and expression of a FRET-based reporter to screen antagonists for the PD-1/PD-L1 complex.

Author(s):
Camarero, Julio A. ; Neamati, Nouri
Author Organization(s):
University of Southern California; University of Michigan
Funding Organization(s):
Publication Date:
2017 Jun 01
Pagination:
0

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Collection: TRECMS
Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
chemical synthesis, chemistry, cells, proteins, mass spectrometry, lepidoptera, peptides, biomedical research, albumins, molecular biology, anti-infective agents, biochemistry, fungi, neoplasms, spectroscopy
Keyword(s):
PD1 PD-L1 Antagonists, Circular Cys-Knotted Micro Proteins, genetically-encoded libraries, cyclotides, MCoTI-I, FRET basedreporters, nmr (nuclear magnetic resonance), immune checkpoints
Update Date:
2018 Apr 30