A Study of the Mechanism of Acute Toxic Effects of Hydrazine, UDMH, MMH, AND SDMH.

reportActive / Technical Report | Accesssion Number: AD0601234 | Open PDF

Abstract:

The mechanism and site of toxic activity of hydrazine, UDMH (1,1-dimethylhydrazine), MMH (methylhydrazine), and SDMH (1,2-dimethylhydrazine) were investigated by acute toxicity studies in mice, by studying cardiovascular and autonomic effects in dogs, by noting the effect on convulsions of transection of the central nervous system at several levels in dogs, and by evaluating selected protective agents in mice. Four separate mechanisms of action are suggested by differences in pharmacologic activity. SDMH has a markedly delayed toxicity, in mice, as compared to the other hydrazines. MMH manifests its MAO inhibitory activity by intensifying the response to tyramine. Hydrazine convulsions are cortical in origin, while UDMH, SDMH and MMH convulsions originate in a pre-pontine area. Protection from convulsions and death due to hydrazine is afforded, in mice, by arginine or ornithine. Protection is provided from the effects of both UDMH and MMH, in mice, by pyridoxine and amino-oxyacetic acid. p-chlorobenzaldehyde and p-nitrobenzaldehyde protect against the effects of UDMH, but not MMH; p-dimethylaminobenzaldehyde protects against the effects of MMH but not UDMH.

Author(s):
Weir, Francis W. ; Nemenzo, Jesus H. ; Bennett, Swanson ; Meyers, Frederick H.
Author Organization(s):
HINE LABS INC SAN FRANCISCO CA
Funding Organization(s):
Aerospace Medical Research Laboratories, Wright-Patterson AFB , OH
Document Type:
Technical Report/Technical Report
Publication Date:
1964 Apr 01
Pagination:
34

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution Code:
A - Approved For Public Release
Distribution Statement: Public Release

RECORD

Collection: TRECMS
Identifying Numbers
Report Number(s):
AMRL-TDR-64-26
Contract Number(s):
DA18-108-AM-19A
Task Number(s):
02
Project Number(s):
6302
Subject Terms
Modernization Areas:
Microelectronics
Communities of Interest:
Biomedical
Descriptor(s):
chemical synthesis, health services, chemistry, brain, organic chemistry, heart rate, hydrazines, toxicology, nervous system, air force, central nervous system, central nervous system stimulants, arteries, pharmacology, spinal cord, standards
Keyword(s):
DIMETHYL HYDRAZINE (1 2), MMH
Subject Categories:
Chemistry
Update Date:
2023 Mar 30