Wakening Substances: Caffeine (Substance eveillante: la cafeine)

reportActive / Technical Report | Accession Number: ADP013768 | Open PDF

Abstract:

Caffeine is the most widely used psychostimulant, whose acceptance, tolerance and side effects are well known. The development of a slow released SRC formulation optimizes caffeine as a fatigue and sleep deprivation counter-measure. Due to its pharmacokinetic properties delayed T sub max and reduced C sub max, a single 300 mg SRC oral dose per day is effective to maintain alertness and performance, up to 45 hours in a total sleep deprivation situation. Compared to other psychostimulants like amphetamines or modafinil, slow released caffeine offers the best ratio effectivenesstolerance-acceptance. Therefore SRC potential use in the military is wider than these exotic drugs, and could benefit to military personnel submitted to sustained or continuous operations.

Author(s):
Lagarde, Didier ; Sicard, Bruno ; Chauffard, Francoise ; Beaumont, Maurice
Author Organization(s):
INSTITUT DE MEDECINE AEROSPATIALE DU SERVICE DE SANTE DES ARMEES CEDEX (FRANCE)
Supplementary Note:
X Dec 2002 to x Dec 2002 Paper presented at the RTO HFM Lecture Series on "Sleep/Wakefulness Management in COntinous/Sustained Operations", p8-1/810, 17-18 Jun 2002, Fort Rucker, Alabama. This article is from ADA412900 Sleep/Wakefulness Management in Continuous/Sustained Operations
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
X5
 Subject Terms
Joint Capability Areas:
JCA_4.4.1_Food Service; JCA_4.4_Logistics Services
Communities of Interest:
Human Systems
Descriptor(s):
*SLEEP DEPRIVATION, *ORAL INTAKE, *CAFFEINE, *FATIGUE(PHYSIOLOGY), MILITARY OPERATIONS, MILITARY PERSONNEL, REDUCTION, FRANCE, DOSAGE, PHARMACOKINETICS, DRUGS, CONTINUITY, ATTENTION, COUNTERMEASURES, AMPHETAMINES
Field(s)/Group(s):
Biochemistry, Stress Physiology, Pharmacology
Keyword(s):
COMPONENT REPORTS, FOREIGN REPORTS, WAKENING SUBSTANCES
Report Date:
2002 Nov 01
Creation Date:
2003 May 28