The Rational Design of Peptide Serine Protease Inhibitors,

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Abstract:

Since the uncontrolled activity of serine protease enzymes is widely implicated in the pathology of disease states involving tissue destruction, there is considerable therapeutic potential for molecules designed specifically to inhibit these enzymes. In the work outlined below, the aim has been to develop a small synthetic peptide inhibitor of the serine protease, human neutrophil elastase HNE for the treatment of pulmonary emphysema.

Author(s):
Wibley, K. S. ; Bansal, S. ; Barlow, D. J.
Author Organization(s):
KING'S COLL LONDON (UNITED KINGDOM)
Supplementary Note:
This Article is from 'Peptides, Chemistry and Biology: Proceedings of the American Peptide Symposium (12th) Held in Cambridge, Massachusetts on 16-21 June 1991', AD-A256 113, p803-805.
Pagination:
0003

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
USAMRDC
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*ENZYME INHIBITORS, *PEPTIDE HYDROLASES, SERINE, EMPHYSEMA, GREAT BRITAIN
Field(s)/Group(s):
Biochemistry, Pharmacology
Keyword(s):
Serine proteases, *Elastases, HNE(Human Neutrophil Elastase), Component Reports
Report Date:
1992 Jan 01