Magnetically-Localizable, Polymerized Lipid Vesticles and Method of Disrupting Same.

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Abstract:

It is an object of this invention to provide lipid vesicles that are stable in vivo to unintended physical and chemical disruption. A further object of this invention is to provided vesicles with polymerizable membranes. A further object of this invention is to provide vesicles that can carry aqueous solutions of therapeutic agents. A further object of this invention is to provide vesicles that can be immoblized at an in vivo target site by an external magnetic field. A further object of this invention is to control the rate of release of an encapulated therapeutic agent at the target site by oscillating the magnetic field. These and other objects are achieved by encapsulating therapeutic agents and ferromagnetic particles in a lipid vesicle formed using polymerizable lipids whichare subsequently polymerized to form a stable vesicle resistant to chemical and physical attack. The vesicles are attracted to the targeted site by an external magnetic field. Once localized at the target site, an oscillating magnetic field is used to destabilize the vesicle membrane resulting in controlled release of the therapeutic agent at the target site. This is a patent application.

Author(s):
Chang, E. L.
Author Organization(s):
DEPARTMENT OF THE NAVY WASHINGTON DC
Descriptive Note:
Patent Application,
Pagination:
0016

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Availability: This Government-owned Invention Available For U.s. Licensing And, Possibly, For Foreign Licensing. Copy Of Application Available Ntis.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
PAT-APPL-714 711
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*PATENT APPLICATIONS, *CAVITIES, *LIPIDS, *CAPSULES(PHARMACY), ATTACK, CAVITIES, CHEMOTHERAPEUTIC AGENTS, EXTERNAL, FERROMAGNETIC MATERIALS, IN VIVO ANALYSIS, INVENTIONS, LIPIDS, MAGNETIC FIELDS, OSCILLATION, PARTICLES, PHYSICAL PROPERTIES, POLYMERIZATION, RATES, RELEASE, SITES, SOLUTIONS(MIXTURES), STABILITY, CHEMICAL ATTACK(DEGRADATION), RESISTANCE
Field(s)/Group(s):
Pharmacology
Report Date:
1985 Mar 12