The Improvement of Plaque Dispersing Enzymes as Oral Therapeutic Agents by Molecular Alteration.

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Abstract:

An oral therapeutic substance is formed by modifying a plaque-dispersing enzyme to control and reduce the occurrence of dental caries and periodontal diseases. In one embodiment, the modification is performed by introducing a suitable complexing reagent in combination with carrier and plaque-dispersing glucanohydrolase molecules to molecularly alter the glucanohydrolase. The modification, while having insignificant effects on the catalytic activity of the enzyme, will increase the binding capability of the enzyme to substances of which the tooth surface is formed. The activity of the enzyme on the tooth surface will therefore be maintained for longer periods of time to combat plaque build-up. Author

Author(s):
Simonson, L. G. ; Lamberts, B. C.
Author Organization(s):
DEPARTMENT OF THE NAVY WASHINGTON D C
Descriptive Note:
Patent Application,
Pagination:
0016

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Availability: This Government-owned Invention Available For U.s. Licensing And, Possibly, For Foreign Licensing. Copy Of Application Available Ntis.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
PAT-APPL-821 275
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*Patent applications, *Dental plaque, *Oral hygiene, *Enzymes, *Dental equipment, Oral bacteria, Streptococcus mutans, Stability, Therapy, Glucanase enzymes
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
Dextranase, Glucanohydrolase
Report Date:
1977 Aug 03