Role of the EGF-Related Growth Factor cripto in Murine Mammary Tumorigenesis

reportActive / Technical Report | Accession Number: ADB267654 | Open PDF

Abstract:

We have investigated the biological and biochemical functions of the Cripto gene, which encodes an extracellular protein that is a member of the EGF-CFC gene family, and which has been implicated in autocrineparacrine signaling during human breast carcinogenesis. To elucidate the potential role of Cripto in mammary development and tumorigenesis, we have analyzed the in vivo activities of Cripto using transgenic mice that overexpress Cripto in the mammary gland, as well as the molecular mechanisms of CRIPTO protein function. In the past four years, we have generated molecular genetic and biochemical lines of evidence that Cripto acts as an essential co-factor for signaling by the divergent TGF- factor Nodal. These findings provide a model for potential mechanisms of Cripto function through modulation of specific TGF--related signals in mammary development and tumorigenesis.

Author(s):
Shen, Michael M.
Author Organization(s):
ROBERT WOOD JOHNSON MEDICAL SCHOOL PISCATAWAY NJ
Descriptive Note:
Final rept. 23 Sep 1996-22 Sep 2000
Supplementary Note:
--Original contains color plates: All DTIC reproductions will be in black and white.
Pagination:
0045

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-96-1-6323
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_1.2.3_Educating; JCA_1.2.7_Experimentation; JCA_1.3.2_Personnel Management; JCA_4.3_Maintain
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*BREAST CANCER, PROTEINS, NEOPLASMS, GENES, IMMUNOASSAY, EPIDERMIS, MAMMARY GLANDS, SPECTRAL LINES, GROWTH(PHYSIOLOGY), TRANSCRIPTION(GENETICS), ONCOGENESIS
Field(s)/Group(s):
Anatomy and Physiology, Medicine and Medical Research
Keyword(s):
*CRIPTO GENE, *MURINE, EGF(EPIDERMAL GROWTH FACTOR), TUMORIGENESIS
Report Date:
2000 Oct 01
Creation Date:
2001 Jul 05