Crossover Comparison of the Pharmacokinetics of Atropine and Pralidoxime Chloride in Three Multichambered Autoinjector Systems and the Mark 1. Task 90-15

Eight sheep were injected in a crossover study with four different auto injectors with at least a 1-week wash out between auto injectors. The pharmacokinetics of atropine and pralidoxime chloride was used to compare the different auto injectors against the standard Mark I. Results were normalized for dose since there was significant difference in the doses contained between the different auto injectors. When two of the auto injectors MCA-A and MCA-B were used, the atropine and 2-PAM were absorbed more rapidly than with the standard or the third auto injector MCA. The maximum 2-PAM concentrations were also higher with these two. The MCA-A resulted in higher maximum atropine concentrations.