Influence of Organophosphate and Anticholinergic Agents on CA++ -Dependent Processes in Synaptic Transmission.
Abstract:
The present report reviews progress over a period of 28 months in studies concerning the effects of organophosphates and anticholinergic agents on Ca -dependent processes in synaptic transmission. Processes which were studied include voltage-dependent and receptor operated Ca channels, NaCa exchange, CaMg -ATPase plasma membrane pump, and ATP-dependent Ca uptake into endoplasmic reticulum. Initial studies focused on the effect of muscarinic receptor agonists on voltage-dependent Ca channels, CaMg -ATPase, ATP-dependent Ca uptake, and NaCa exchange in rat brain synaptosomes and synaptosomal membranes. These studies characterized two phases of Ca influx and time courses for Ca entry. Acute in vitro soman treatment 50 microns for 2 min did not alter Ca influx through voltage-operated channels. Keywords Acetylcholine Organophosphates Calcium transport Synaptosome Pharmacology. JES