Preformulation Studies of Selected Pretreatment and Therapeutic Compounds

reportActive / Technical Report | Accession Number: ADB094143 | Open PDF

Abstract:

This annual report represents preformulation and formulation and production projects conducted in the fourth year of this contract on the following drugs WR6026-2HC1 WR638 WR180,409-H3PO4 WR142,490-HC1 WR171,669-HC1 and Formycin B,5 Monophosphate. This work consists of the physicochemical characterization of WR6026-2HC1 including stability studies formulation and production of WR638 capsules formulation and production of WR180,409-H3PO4 tablets and matching placebos coating of WR142,490-HC1 tablets and formulation and production of matching placebos the preparation of capsules containing 14C labelled WR171,669-HC1 with polyvinylpyrrolidone and the development of liposomes containing formycin B,5 monophosphate.

Author(s):
Lach, John L. ; Flanagan, Douglas R. ; Matheson, Lloyd E., Jr
Author Organization(s):
IOWA UNIV IOWA CITY COLL OF PHARMACY
Descriptive Note:
Annual progress rept. 1 Jul 1982-30 Jun 1983
Supplementary Note:
DOI: 10.21236/ADB094143
Pagination:
0174

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release, Document Partially Illegible
Distribution Statement:
Availability: Document Partially Illegible.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-79-C-9136
Task Number(s):
AB
Project Number(s):
3M4663764D995
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_1_Force Support; JCA_1.2_Force Preparation; JCA_1.2.3_Educating; JCA_5_Command and Control; JCA_5.3_Planning; JCA_6.3.3_Spectrum Management; JCA_6_Net Centric; JCA_6.4.1_Secure Information Exchange; JCA_6.3_Net Management; JCA_1.2.5_Lessons Learned; JCA_3.2_Engagement; JCA_3_Force Application; JCA_6.4_Information Assurance; JCA_3.2.1_Kinetic Means; JCA_5.2_Understand; JCA_4_Logistics
Modernization Areas:
Directed Energy
Communities of Interest:
Biomedical
Descriptor(s):
*DRUGS, *CHEMOTHERAPEUTIC AGENTS, STABILITY, PRODUCTION, CYTOPLASM, PLACEBOS, MATCHING, CHEMOTHERAPY
Field(s)/Group(s):
Pharmacology
Keyword(s):
LIPOSOMES, WR6026, WR638, WR180, 409, WR142, 490, WR171, 669, FORMYCIN B, 5 MONOPHOSPHATE, PE63764A, WU042
Report Date:
1983 Jul 01