Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition

reportActive / Technical Report | Accession Number: ADA625406 | Open PDF

Abstract:

The sublaterodorsal SLD nucleus is hypothesized to induce muscle atonia during rapid eye movement REM sleep. This was tested by injecting channelrhodopsin into the SLD of 5 rats, followed by a series of behavioral tests. Results confirmed our ability to rapidly induce muscle atonia following optogenetic stimulation of the SLD, suggesting that activation of the SLD is sufficient to cause a REM atonia like state.

Author(s):
Good, Cameron H. ; Jhou, Thomas ; Burnham, Nathan
Author Organization(s):
MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON
Supplementary Note:
The original document contains color images. DOI: 10.21236/ADA625406
Pagination:
0024

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
ARL-CR-0783
Contract/Grant Number(s):
1120-1120-99
Monitor Series:
ARL*
 Subject Terms
Joint Capability Areas:
JCA_1.2.1_Training; JCA_1.2.7_Experimentation; JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.3_Educating
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*EYE MOVEMENTS, ACTIVATION, MUSCLES, RAPID DEPLOYMENT, SKILLS, SLEEP, STIMULATION(GENERAL)
Field(s)/Group(s):
Anatomy and Physiology
Keyword(s):
OPTOGENETIC, SUBLATERODORSAL NUCLEUS, ATONIA
Report Date:
2015 Sep 01
Creation Date:
2016 Jan 20