Expression of Proteins Involved in Epithelial-Mesenchymal Transition as Predictors of Metastasis and Survival in Breast Cancer Patients

reportActive / Technical Report | Accession Number: ADA603895 | Open PDF

Abstract:

The purpose of this research is to investigate protein expression and promoter region DNA methylation status of six genes involved in epithelial-mesenchymal transition in relation to breast cancer lymph node metastasis, recurrence, and survival. Breast tumor tissue has been retrospectively identified from the Pathology Resource and immunohistochemical staining for all proteins has been completed. Scoring and analysis of IHC assays is ongoing. FFPE tissue cores for a subset of the IHC-stained tissues have been procured for isolation of DNA and methylation assay.

Author(s):
Roberts, Michelle ; Bshara, Wiam ; Higgins, Michael ; Freudenheim, Jo ; Das, Gokul ; Miller, Austin ; Ambrosone, Christine
Author Organization(s):
HEALTH RESEARCH INC BUFFALO NY
Descriptive Note:
Revised annual summary rept. 1 Nov 2012-31 Oct 2013
Pagination:
0019

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-11-1-0024
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.3_Educating; JCA_1.2.5_Lessons Learned; JCA_4_Logistics; JCA_5.5.2_Task; JCA_5.5_Direct
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*BREAST CANCER, *EPITHELIUM, *HISTOCHEMISTRY, *IMMUNOLOGY, *METASTASIS, BIOLOGICAL STAINS, GENES, LYMPH, MAMMARY GLANDS, METHYLATION, NEOPLASMS, NODES, PATHOLOGY, PATIENTS, PROTEINS, SURVIVAL(PERSONNEL), TISSUES(BIOLOGY)
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
MOLECULAR EPIDEMIOLOGY, EPITHELIAL MESENCHYMAL TRANSITION, METASTASIS SUPPRESSOR GENES, IMMUNOHISTOCHEMISTRY, DNA METHYLATION
Report Date:
2013 Nov 01
Creation Date:
2014 Aug 06