Analysis of Novel Prostate Cancer Biomarkers and their Predictive Utility in an Active Surveillance Protocol
Abstract:
The Research Project supported by this DOD PCRP Physician Research Training Award investigates novel biomarkers for prostate cancer detection and prediction of disease outcome. The goals and objectives of this study are summarized by the Specific Aims 1. Evaluate the relative levels of expression of our panel of candidate protein biomarkers in urine, tissue and serum from patients with prostate cancer compared with normal controls to identify prostate cancer specific biomarkers. 2. Evaluate the relative urine, tissue and serum levels of these prostate cancer specific biomarkers within our entire active surveillance AS cohort to identify accurate biomarkers predictive of indolent vs. progressive prostate cancer. The funding from this Physician Research Training Award provides salary support for Dr. Adam S. Feldman to secure protected time as a translational and clinical investigator in prostate cancer research. It also provides salary support for a Research Assistant for this project.