Xenon as a Neuroprotectant in Traumatic Brain Injury

The purpose of this novel study is to determine if xenon has a neuroprotectant effect in an vivo animal models of TBI. The project scope is an early proof of concept in rat models of xenon neuroprotection. The Specific Aims are to determine the effect of inhaled xenon on brain histopathology, behavior, in short- and long-term fluid percussion FP and controlled cortical impact CCI rat models of TBI compared to controls. The scope of this project is proof of concept in a rat model. Major findings and progress We developed a recirculation xenon device for this project. Xenon and devices for behavioral studies acquired. IACUC and VA Research Approvals had been obtained. We believed ACURO approval was in place, but discovered late that it was not. We halted animal work immediately, and re-designed and submitted the appended Statement of Work, which was approved. Animal work generated without ACURO approval cannot be used. ACURO approval will be needed prior to starting this work.