Prevention of Stimulant Induced Euphoria with an Opioid Receptor Antagonist

reportActive / Technical Report | Accession Number: ADA591377 | Open PDF

Abstract:

The protocol, sponsored by the Department of Defense, is a 6-week study examining whether Methylphenidate-induced euphoria can be attenuated by co-administration with Naltrexone In medication native young adults age 18-30 with a euphoric response to MPH administered on the Drug Feeling visit. In this double bind study, subjects will receive MPH and Naltrexone or a placebo to treat their ADHD symptoms over the course of the 6-week trial.

Author(s):
Spencer, Thomas J.
Author Organization(s):
MASSACHUSETTS GENERAL HOSPITAL BOSTON
Descriptive Note:
Annual rept. 30 Sep 2012-29 Sep 2013
Supplementary Note:
The original document contains color images. DOI: 10.21236/ADA591377
Pagination:
0019

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-12-1-0510
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_1_Force Support; JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_1.2_Force Preparation; JCA_1.2.1_Training; JCA_6_Net Centric; JCA_1.3_Human Capital Management; JCA_6.1_Information Transport; JCA_5_Command and Control; JCA_1.3.2_Personnel Management; JCA_6.4.1_Secure Information Exchange; JCA_8_Building Partnerships; JCA_1.2.3_Educating; JCA_1.3.1_Personnel and Family Support; JCA_8.2_Shape; JCA_6.4_Information Assurance
Communities of Interest:
Biomedical
Descriptor(s):
*ATTENTION, *BEHAVIOR, *MENTAL DEFICIENCY, ADULTS, CLINICAL TRIALS, MEDICINE, METHYLPHOSPHONATES, NARCOTICS, PHARMACOLOGICAL ANTAGONISTS, PLACEBOS, PREVENTION, RECEPTOR SITES(PHYSIOLOGY), SIGNS AND SYMPTOMS
Field(s)/Group(s):
Anatomy and Physiology, Medicine and Medical Research, Stress Physiology
Report Date:
2013 Oct 01
Creation Date:
2014 Jan 27