Repair of Nerve Cell Membrane Damage by Calcium-Dependent, Membrane-Binding Proteins (Revised)

reportActive / Technical Report | Accession Number: ADA582943 | Open PDF

Abstract:

In the second year of this contract calcium-dependent, membrane-binding proteins of the annexin class were found to be effective at preventing damage and repairing damage to membranes caused by osmotic shock or other chemical and physical stresses using an in vitro assay involving synthetic membrane vesicles. These proteins may therefore be promising agents for protecting or promoting the repair of cell membranes in the case of spinal cord injury.

Author(s):
Creutz, Carl E.
Author Organization(s):
VIRGINIA UNIV CHARLOTTESVILLE
Descriptive Note:
Annual rept. 1 Sep 2011-31 Aug 2012
Pagination:
0020

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-10-1-0777
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_1.2.7_Experimentation; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.2_Non-Kinetic Means; JCA_1_Force Support; JCA_4.3_Maintain; JCA_1.3_Human Capital Management; JCA_1.3.2_Personnel Management; JCA_5_Command and Control; JCA_8_Building Partnerships; JCA_8.2_Shape; JCA_5.3_Planning; JCA_8.2.1_Partner with Governments and Institutions
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CALCIUM, *NERVE CELLS, *PROTEINS, CHOLINES, DAMAGE, GLYCEROLS, LEAKAGE(FLUID), LIPOSOMES, MEMBRANES, OSMOTIC PRESSURE, PEPTIDES, PERMEABILITY, REPAIR, SPINAL CORD, WOUNDS AND INJURIES
Field(s)/Group(s):
Biochemistry, Anatomy and Physiology, Inorganic Chemistry
Keyword(s):
MEMBRANE REPAIR, SPINAL CORD INJURIES, NERVE CELL MEMBRANE DAMAGE, CALCIUM DEPENDENT MEMBRANE BINDING PROTEINS, ANNEXINS, ARACHIDONIC ACIDS, LPA(LYSOPHOSPHATIDIC ACID), LPC(LYSOPHOSPHATIDYLCHOLINE), MEMBRANE PERMEABILITY BARRIER, DIACYLGLYCEROLS, MONOACYLGLYCEROLS, SPERMIDINES, AMYLINS, OSMOTIC SHOCK
Report Date:
2012 Sep 01
Creation Date:
2013 Sep 11