Development of Advanced Technologies for Complete Genomic and Proteomic Characterization of Quantized Human Tumor Cells

reportActive / Technical Report | Accession Number: ADA574964 | Open PDF

Abstract:

Through this collaborative research effort, we intend to develop quantitative tools with direct applications for patients with glioblastoma. We will pursue new strategies for genome sequencing and new technologies for the genetic analyses of cancer mechanisms, as well as methods for assessment of progression and stratification of human glioblastoma. This proposal will significantly advance genomic, proteomic and single-cell technologies, and the proposed tools will be generally applicable to all cancer-based studies to identify and quantify DNA, RNAs, proteins and cells, challenges ubiquitous to all human disease systems.

Author(s):
Foltz, Gregory
Author Organization(s):
SWEDISH EPILEPSY CENTER SEATTLE WA
Descriptive Note:
Annual rept. 15 Jun 2011-14 Jun 2012
Supplementary Note:
DOI: 10.21236/ADA574964
Pagination:
0005

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-11-1-0488
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning
Modernization Areas:
Microelectronics
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CANCER, *CELLS(BIOLOGY), *GENETICS, *PROTEOMICS, GENOME, NEOPLASMS, PATIENTS, STRATIFICATION, TOOLS
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
HUMAN COHORTS, GLIOBLASTOMA, GENOMIC, PROTEOMIC, SINGLE CELL TECHNOLOGIES, HYPOTHESIS DRIVEN, INTEGRATIVE SYSTEMS APPROACH, EARLY DIAGNOSIS, PATIENT STRATIFICATION, BLOOD PROTEIN BIOMARKERS, QUANTIZED CELL POPULATIONS
Report Date:
2012 Jul 01
Creation Date:
2013 May 20