Hyaluronan-CD44 Interactions Decrease the Metastatic Potential of Breast Cancer Cells

reportActive / Technical Report | Accession Number: ADA572527 | Open PDF

Abstract:

The adhesion receptor CD44 is known to decrease the metastatic potential of breast cancer cells in vivo. This study focuses on understanding the mechanisms by which CD44 inhibits breast cancer cell invasion. We have found that the differential interaction between CD44 and soluble or embedded Hyaluronan leads to differential phosphorylation of ERK and Pak. These differentially activated signaling pathways molecularly govern a phenotypic switch between invasiveness or proliferation. Additionally, this interactions also leads to decreased transcription of the metalloprotease MMP9 when on collagen IV gels but not collagen I gels. Together, these mechanisms provide significant insight into how CD44 inhibits the movement of breast cancer cells away from their primary site.

Author(s):
Lopez, Jose I.
Author Organization(s):
ARIZONA UNIV TUCSON
Descriptive Note:
Annual summary rept. 1 Jun 2007-31 May 2008
Supplementary Note:
The original document contains color images. DOI: 10.21236/ADA572527
Pagination:
0037

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-06-1-0455
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_1.3.2_Personnel Management; JCA_5_Command and Control; JCA_4.3_Maintain; JCA_1.2.5_Lessons Learned; JCA_5.3_Planning; JCA_1.2.3_Educating
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*BREAST CANCER, *CELLS(BIOLOGY), *IN VIVO ANALYSIS, *METASTASIS, ADHESION, COLLAGEN, GELS, INTERACTIONS, PHOSPHORYLATION, SENSE ORGANS, SOLUBILITY
Field(s)/Group(s):
Medicine and Medical Research
Report Date:
2008 Jun 01
Creation Date:
2013 Apr 22