A Comparison of Proximal Tibia and Proximal Humerus Infusion Rates of Plasma Under High Pressure Using the EZ IO Intraosseous Device in the Adult Swine (Sus scrofa) Hypovolemic Model

reportActive / Technical Report | Accession Number: ADA570999 | Open PDF

Abstract:

Purpose Evaluate use of plasma admin via IO under pressure 300mmHg in proximal humerus and tibia, establish which IO sites reach higher flow rate, and eval for pulmonary fat emboli-FE post IO infusion. Method2 groups of swine-16 each intubated and ventilated. Central venous and arterial lines placed blood removed at rate of 2.15mlmin for 7min, then 1.15mlmin for 13min. Swine observed with no treatment for 1hr. EZIO needle inserted plasma reinfused for 10min. Lung samples eval for signs of FE. Findings The mean weight, vol removed and infusion pressure were similar in both groups. Mean vol plasma infused 490mL tibia and 649mL humerus. Mean infusion rate was 49mLminSD22mLmin tibia and 78mLminSD43mLmin humerus p0.02. Survival rate 94 tibia, 88 humerus p0.33. Humerus serum lactate elevated during 1hr post bleed decreased post plasma infusion tibia elevated until EOS. Histo revealed FE present 88 tibia, 94 humerus. ConclusionIO infusion rate of plasma in humerus greater than tibia in swine model. Majority of swine had FE in lungs. Further studies needed to eval safety of high pressure infusion in IO device.

Author(s):
Lairet, Julio ; Bebarta, Vikhyat
Author Organization(s):
AIR FORCE MEDICAL WING (59TH) WILFORD HALL AMBULATORY SURGICAL CENTER LACKLAND AFB TX
Descriptive Note:
Final rept. May 2011-Dec 2012
Supplementary Note:
Protocol Number: FWH20100171A. The original document contains color images. DOI: 10.21236/ADA570999
Pagination:
0004

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
OTSG-SGRS/MD
 Subject Terms
Joint Capability Areas:
JCA_6_Net Centric; JCA_1.2.5_Lessons Learned; JCA_6.1_Information Transport; JCA_5.3_Planning; JCA_5_Command and Control
Communities of Interest:
Biomedical
Descriptor(s):
*BLOOD PLASMA, EMBOLISM, FAT CELLS, HUMERUS, INFUSIONS, LACTATES, LUNG, PRESSURE, RESUSCITATION, SWINE, TIBIA
Field(s)/Group(s):
Anatomy and Physiology, Medicine and Medical Research
Keyword(s):
EZIO, INTRAOSSEOUS, INTRAOSSEOUS INFUSION, IO(INTRAOSSEOUS), PLASMA INFUSION, SUS SCROFA, PULMONARY FAT EMBOLISM, SURVIVAL RATE, SERUM LACTATES
Report Date:
2013 Jan 10
Creation Date:
2013 Apr 01