Delta-Tocotrienol: Radiation Protection and Effects on Signal Transduction Pathways

reportActive / Technical Report | Accession Number: ADA553084 | Open PDF

Abstract:

Summary and Conclusions Survival of gamma-irradiated mouse bone marrow and primary human hematopoietic CD34 cells was significantly enhanced by Delta-tocotrienol DT3. DT3 dramatically induced Erk phosphorylation and decreased the DNA-damage marker gamma-H2AX foci formation. DT3 reversed the radiation-inhibited mTOR and S6 protein activation, and induced 4EBP-1 phosphorylation. Knockdown of Erk gene expression by siRNA abrogated DT3-induced mTOR phosphorylation, induced gamma-H2AX foci formation, and inhibited clonogenicity in CD34 cells. In conclusion, our data suggest DT3 effectively protects mouse bone marrow and human CD34 cells from radiation damage through the ErkmTOR survival pathway Hematological 2010 9512 1996-2004.

Author(s):
Srinivasan, Venkataraman ; Xiao, Mang
Author Organization(s):
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Descriptive Note:
Briefing charts
Supplementary Note:
Presented during the Radiation Countermeasures Symposium, June 15, 2011 Armed Forces Radiobiology Research Institute at the Uniformed Services University in Bethesda, Maryland. The original document contains color images.
Pagination:
0025

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
AFRRI
 Subject Terms
Joint Capability Areas:
JCA_1.2.5_Lessons Learned
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*RADIATION DAMAGE, *TRANSDUCERS, BONE MARROW, BONES, CELLS, GENES, HEMATOLOGY, HUMANS, MICE, PHOSPHORYLATION, RADIATION PROTECTION, REVERSIBLE, SIGNALS, SURVIVAL(GENERAL)
Field(s)/Group(s):
Radiobiology
Keyword(s):
CONTAIN BRIEFING CHARTS ONLY
Report Date:
2011 Jun 15
Creation Date:
2012 Jan 18