Hemoglobin-based Oxygen Carrier (HBOC-201) and Escalating Doses of Recombinant Factor VIla (rFVIIa) as a Novel Pre-hospital Resuscitation Fluid in a Swine Model of Severe Uncontrolled Hemorrhage

Scultetus, Anke; Arnaud, Francoise; Kaplan, Lewis; Shander, Aryeh; Philbin, Nora; Rice, Jennifer; Mccarron, Richard; Freilich, Daniel

Hemoglobin-based Oxygen Carrier (HBOC-201) and Escalating Doses of Recombinant Factor VIla (rFVIIa) as a Novel Pre-hospital Resuscitation Fluid in a Swine Model of Severe Uncontrolled Hemorrhage

Active / Technical Report | Accession Number: ADA552326 |

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Abstract:

Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC90, 180 or 360 J.lgkg rFVIIa before hospital arrival at 240 min animals survived to 72 hours. Blood loss was reduced MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and I 80 J.lgkg rFVIIa groups. Lactate was cleared faster in the HBOCrFVIIa 90 J.lgkg group. Verification in a large, well-powered study is indicated.

Author(s):

Scultetus, Anke ; Arnaud, Francoise ; Kaplan, Lewis ; Shander, Aryeh ; Philbin, Nora ; Rice, Jennifer ; Mccarron, Richard ; Freilich, Daniel

Author Organization(s):

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Descriptive Note:

Journal article

Supplementary Note:

Pub. in Artificial Cells, Blood Substitutes, and Biotechnology, v39, p59-68, 2011.

Pagination:

0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

Distribution Statement:

Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR

Identifying Numbers

Monitor Series:

NMRC/MD

Subject Terms

Joint Capability Areas:

JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_4.6.1_General Engineering; JCA_4.6_Engineering; JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.3_Educating; JCA_1.2.7_Experimentation

Modernization Areas:

Biotechnology

Communities of Interest:

Biomedical

Descriptor(s):

*BLOOD DISEASES, *DOSAGE, *LIVER, *LOSSES, *SWINE, *WOUNDS AND INJURIES, BLOOD, HEMORRHAGE, HOSPITALS, LACTATES, OXYGEN, RESUSCITATION, TRAUMA

Field(s)/Group(s):

Medicine and Medical Research

Keyword(s):

*BLOOD LOSS, *HBOC(HEMOGLOBIN BASED OXYGEN CARRIERS), HBOC 201, PRE HOSPITAL TRAUMA CARE, RFVLLA

Report Date:

2010 Jan 01

Creation Date:

2011 Dec 19