NCCU/BBRI-Duke/Urology Partnership In Prostate Cancer Research

The NCCUBBRI-DukeUrology Partnership in Prostate Cancer Research was developed to promote Collaborative Training, Research, and Community Dialogue and Outreach among scientists from NCCU and Duke. During the first funding period, NCCU scientists, with the expertise of their Duke partners, have started five collaborative pilot projects. These projects have provided needed training for NCCU scientists in the development and approval of IRB protocols for research involving human subjects, and access to key core facilities and libraries at Duke. Some reagents important to the success of the projects have been developed including a mouse model of prostate cancer deficient in beta arrestin 2 TRAMP-beta arr2 or 5-Lox TRAMP- Alox5. Several prostate cancer cell lines have also been adapted to the principal investigators laboratories for in vitro studies. Our collaboration has also led to the submission of three grant proposals one to the USAMRMC and two to the National Institute of Health. The USARMC proposal entitled Association of the UGT2B17 Gene Deletion Polymorphism and the Incidence of Ovarian Cancer and Ethnicity and the Export project entitled Roles of Inflammation and Androgen Metabolism in Prostate Cancer Disparity have been funded. The revised U54 application in partnership with UNC-Lineberger Comprehensive Cancer Center entitled NCCU-LCCC Partnership In Cancer Research is currently under review.