Multidisciplinary Analysis of Cyclophilin A Function in Human Breast Cancer

reportActive / Technical Report | Accession Number: ADA543741 | Open PDF

Abstract:

The goal of this project was to understand how cyclophilin A CypA regulates the prolactin receptor PRLr signaling. The data have demonstrated that CypA, serving as a molecular switch via its peptidyl-prolyl isomerase PPI activity, binds to and regulates the function of the PRLr. Furthermore, point mutagenesis analysis has implied that a single prolyl imide bond Pro-334 within the X-Box motif of intracellular domain of the PRLr is most likely responsible for the observed effects of CypA on the PRLr signaling. Finally, we have conducted several proof-of-concept studies that may lead to novel anti-breast cancer agents.

Author(s):
Zheng, Jiamao
Author Organization(s):
NORTHWESTERN UNIV EVANSTON IL
Descriptive Note:
Annual summary 1 Mar 2008-28 Feb 2011
Supplementary Note:
The original document contains color images. DOI: 10.21236/ADA543741
Pagination:
0031

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-08-1-0169
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_1.2.7_Experimentation; JCA_1.2.5_Lessons Learned; JCA_5.5.2_Task; JCA_5.5_Direct; JCA_1.3.2_Personnel Management; JCA_5.2_Understand; JCA_5.3.3_Develop Strategy; JCA_5.2.3_Share Knowledge and Situational Awareness; JCA_5.3.4_Develop Courses of Action; JCA_5.3.5_Analyze Courses of Action; JCA_1.2.3_Educating; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_5.2.2_Develop Knowledge and Situational Awareness
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*BREAST CANCER, *PROLACTIN, ANTIBODIES, CELLS(BIOLOGY), GENE EXPRESSION, RECEPTOR SITES(PHYSIOLOGY), PROTEINS, PEPTIDES, RIBONUCLEIC ACIDS
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research, Pharmacology
Keyword(s):
CYPA(CYCLOPHILIN A), PRLR(PROLACTIN RECEPTORS), JAK2, CYCLOSPORINE A, RNAI, PEPTIDE INHIBITORS, SYNTHETIC ANTIBODIES, PPI(PEPTIDYL PROLYL ISOMERASES), XBOX MOTIF
Report Date:
2011 Mar 01
Creation Date:
2011 Jun 29