Oxidative Stress, DNA Repair and Prostate Cancer Risk

Oxidative stress, which results from an imbalance between ROS and antioxidant capacities, can cause a wide range of direct or indirect DNA damage. There are extensive DNA repair systems that can correct DNA damage caused by ROS before cell replication and mutation fixation. Although oxidative stress appears to be important in the etiology of prostate cancer, so far there is no study to comprehensively investigate the association between DRC of oxidative DNA damage as a phenotype and prostate cancer risk. We hypothesize that DRC of oxidative DNA damage as a phenotype may modify prostate cancer risk. So far, the study has recruited 287 cases and 276 controls. The proposed molecular analysis has progressed smoothly for all three specific aims.