The STRONG STAR Multidisciplinary PTSD Research Consortium

reportActive / Technical Report | Accession Number: ADA515405 | Open PDF

Abstract:

We propose two experiments addressing the effectiveness of SSRIs for the treatment of PTSD in OEFOIF veterans with combat-related trauma. First we will collaborate with Dr. Young who is conducting a Fluoxetine vs. placebo comparison for the treatment of PTSD among OEFOIF active-duty personal stationed at Fort Hood after their return from deployment in the Middle East. For this study, we will add to the ongoing clinical trial, assessment of drinking behavior and four other measures necessary to derive patients alcohol-related subtype. Second, we will conduct a prospective study comparing the effectiveness of Sertraline vs. Placebo to treat PTSD in OEFOIF veterans who have a PTSD Alcohol Dependence dual diagnosis and are seeking treatment within the VA. For Both studies we hypothesize that alcohol-related subtypes can be derived from amongst the subject population which will predict the outcomes of treatment with the SSRIs. Also, both studies will collect DNA for the assessment of genetic polymorphisms pertinent to the prediction of treatment outcome.

Author(s):
Roache, John D.
Author Organization(s):
TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO
Descriptive Note:
Annual rept. 1 Sep 2008-31 Aug 2009
Supplementary Note:
The original document contains color images.
Pagination:
0038

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-08-2-0117
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.6.1_Assess Compliance with Guidance; JCA_5.6_Monitor; JCA_5.3_Planning; JCA_1.3.2_Personnel Management; JCA_1.2.5_Lessons Learned; JCA_4.1_Deployment and Distribution; JCA_1.2.3_Educating; JCA_1.2.1_Training
Modernization Areas:
AI and Machine Learning
Communities of Interest:
Biomedical
Descriptor(s):
*CLINICAL TRIALS, *SEROTONIN, *POST TRAUMATIC STRESS DISORDER, *ALCOHOLISM, *POLYMORPHISM, BEHAVIOR, PLACEBOS, CONSORTIUMS, HOMING, GENETICS, TRAUMA, ALCOHOL CONSUMPTION, ADDRESSING, DIAGNOSIS(MEDICINE), DEOXYRIBONUCLEIC ACIDS, POPULATION, COMPARISON, WARFARE, PREDICTIONS
Field(s)/Group(s):
Psychology, Anatomy and Physiology, Medicine and Medical Research, Stress Physiology, Test Facilities, Equipment and Methods, Military Forces and Organizations, Organic Chemistry, Weapons Effects (Biological)
Keyword(s):
*PTSD(POST TRAUMATIC STRESS DISORDER), *SSRI(SELECTIVE SEROTONIN REUPTAKE INHIBITORS), OEF(OPERATION ENDURING FREEDOM), OIF(OPERATION IRAQI FREEDOM), OEF OIF, *SERTRALINE, FLUOXETINE, GENETIC POLYMORPHISMS
Report Date:
2009 Sep 01
Creation Date:
2010 Mar 24