Drug Targets in Infections With Ebola and Marburg Viruses

reportActive / Technical Report | Accession Number: ADA513361 | Open PDF

Abstract:

The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

Author(s):
Gene, Olinger G. ; Julia, Biggins E. ; Vanessa, Melanson R. ; Victoria, Wahl-jensen ; Thomas, Geisbert W. ; Lisa, Hensley E.
Author Organization(s):
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Descriptive Note:
Journal article
Supplementary Note:
Pub. in Infectious Disorders-Drug Targets v9, p191-200, 2009.
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
TR-09-014
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5_Command and Control; JCA_5.3_Planning; JCA_5.3.3_Develop Strategy; JCA_1.3.2_Personnel Management; JCA_JCA_4.1.2_Sustain the Force; JCA_4.1_Deployment and Distribution; JCA_4.7.2_Installation Services; JCA_4.7_Base and Installations Support
Communities of Interest:
Biomedical
Descriptor(s):
*ARBOVIRUSES, *INFECTIOUS DISEASES, *DRUGS, *EBOLA VIRUS, PREVENTIVE MEDICINE, VACCINES, ANTIVIRAL AGENTS, TARGETING, VIRUSES
Field(s)/Group(s):
Medicine and Medical Research, Microbiology, Pharmacology
Keyword(s):
*FILOVIRUS, *DRUG TARGETS, *MARBURG VIRUS, DRUG DEVELOPMENT
Report Date:
2009 Jan 01
Creation Date:
2010 Feb 12