Development of Highly Sensitive Bulk Acoustic Wave Device Biosensor Arrays for Screening and Early Detection of Prostate Cancer

reportActive / Technical Report | Accession Number: ADA510112 | Open PDF

Abstract:

In this research, I present several novel contributions to the field of microelectronic acoustic biosensors that approach the goal of developing a cost-effective, highly sensitive and highly selective sensor array for the detection of early cancer proliferation. First I report on the development of a novel solidly mounted shear-mode resonator employing piezoelectric ZnO as an appropriate base device for liquid-phase sensing applications. Second I report on the development of a novel and appropriate chemical surface preparation protocol for the covalent immobilization of monoclonal IgG antibodies to the surface of this device, thereby functionalizing it as a biosensor. Proof of functionality is demonstrated employing these sensors for the detection of various known cancer biomarkers in complex media as well as progress towards developing a packaged disposable sensor array system is also reported.

Author(s):
Dickherber, Anthony J. ; Corso, Christopher D. ; Hunts, William D.
Author Organization(s):
GEORGIA TECH RESEARCH CORP ATLANTA
Descriptive Note:
Annual rept. 1 Jan 2007-31 Dec 2008
Supplementary Note:
Appendices include published journal articles and doctoral thesis, Design and Implementation of an Acoustic Resonator-based Biosensor for the Early Dection of Prostate Cancer, by Anthony Dickherber. The original document contains color images. All DTIC reproductions will be in black and white. DOI: 10.21236/ADA510112
Pagination:
0269

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-07-1-0099
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5.3.4_Develop Courses of Action; JCA_5.3.5_Analyze Courses of Action; JCA_5.3.3_Develop Strategy; JCA_5.3.2_Apply Situational Understanding; JCA_1.2.7_Experimentation; JCA_5.5_Direct; JCA_5.5.1_Communicate Intent and Guidance; JCA_4.6_Engineering; JCA_5.2_Understand; JCA_5.2.3_Share Knowledge and Situational Awareness; JCA_1.2.5_Lessons Learned; JCA_1.2.3_Educating; JCA_1.2.1_Training; JCA_4.3_Maintain; JCA_5.4_Decide; JCA_1.2.6_Concepts
Modernization Areas:
Biotechnology; Microelectronics
Communities of Interest:
Sensors
Descriptor(s):
*PROSTATE CANCER, *ACOUSTIC DETECTION, PIEZOELECTRIC GAGES, PROTEOMICS, MICROELECTRONICS, ANTIGENS
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research, Medical Facilities, Equipment and Supplies, Acoustic Detection and Detectors
Keyword(s):
EARLY DETECTION, BIOSENSORS, MICROELECTRONIC ACOUSTICS, PIEZOELECTRIC RESONATORS, BIOSENSORS, ACOUSTIC RESONATOR ARRAYS, BAW(BULK ACOUSTIC WAVE) DEVICES
Report Date:
2009 Jan 01
Creation Date:
2009 Dec 16