Role of GGAP/PIKE-A in prostate cancer progression

reportActive / Technical Report | Accession Number: ADA510062 | Open PDF

Abstract:

The clinical behavior of prostate cancer is extremely heterogeneous, ranging from indolent disease to aggressive, metastatic cancer with rapid mortality. GGAP2 is a GTPase protein with a GTPase activating protein GAP domain at the C-terminus. It was reported that GGAP2, or PIKE-A, can activate Akt and inhibit apoptosis. The goal of this proposal is characterize the role of GGAP2 in prostate cancer progression. Our results indicate that GGAP2 expression is increased in prostate cancer. In addition, GGAP2 is mutated in human prostate cancer. The multiplicity of GGAP2 mutations imply that these mutations may emerge in an environment of the multifocal heterogeneity of prostate cancer tissues. According to our results these mutations can stimulate cancer cell proliferation and enhance GGAP2 activation, indicating that they may contribute to increased activity of GGAP2 in prostate cancer. In summary, GGAP2 may promote prostate cancer growth and progression via overexpression andor mutation and as such is an important therapeutic target.

Author(s):
Ittmann, Michael M.
Author Organization(s):
BAYLOR COLL OF MEDICINE HOUSTON TX
Descriptive Note:
Annual rept. 15 Apr 2008-14 Apr 2009
Supplementary Note:
The original document contains color images. DOI: 10.21236/ADA510062
Pagination:
0020

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-07-1-0023
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1.2.5_Lessons Learned; JCA_5.3_Planning; JCA_1.2.3_Educating; JCA_5.5.2_Task; JCA_5.5_Direct; JCA_1.2.7_Experimentation
Modernization Areas:
Biotechnology
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*PROSTATE CANCER, MUTATIONS, METASTASIS, PROTEINS, GROWTH(PHYSIOLOGY)
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research
Keyword(s):
GGAP2, GAP(GTPASE ACTIVATING PROTEIN)
Report Date:
2009 May 01
Creation Date:
2009 Dec 16