The Role of ERBP in Breast Cancer Progression

reportActive / Technical Report | Accession Number: ADA501116 | Open PDF

Abstract:

Metastasis likely occurs when primary tumor cells obtain additional genetic or epigenetic alteration. ERBP estrogen receptor binding protein is an estrogen receptor binding protein which potentiates the transcriptional activity of estrogen receptor. Unlike most coactivators which interact with AF2 domain of estrogen receptor, ERBP interacts with the DNA binding domain of estrogen receptor. The altered expression of ERBP could promote the metastasis through enhancing the expression of genes which are regulated by estrogen and are involved in the breast cancer metastasis. By overexpressing ERBP in breast cancer cells, we found that ERBP overexpression enhanced the migration and invasion capability of tumor cells. ERBP overexpression also promoted the tumor formation in nude mice. We identified 8 estrogen inducible genes which were up-regulated by ERBP overexpression. Finally, we found that expression of ERBP is increased in about 30 of breast cancers.

Author(s):
Zhu, Yijun
Author Organization(s):
NORTHWESTERN UNIV EVANSTON IL
Descriptive Note:
Final rept. 1 Sep 2006-31 Aug 2008
Supplementary Note:
DOI: 10.21236/ADA501116
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-06-1-0583
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.5.2_Task; JCA_5.5_Direct
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*BREAST CANCER, *METASTASIS, *ESTROGENS, GENES, MICE, TRANSCRIPTION(GENETICS), SENSE ORGANS, PRIMARY BATTERIES, CHEMICAL BONDS, DEOXYRIBONUCLEIC ACIDS, NEOPLASMS, CELLS(BIOLOGY)
Field(s)/Group(s):
Medicine and Medical Research
Report Date:
2008 Sep 01
Creation Date:
2009 Jul 15